Business Challenge
In upstream and aseptic manufacturing environments, Biosafety Cabinets (BSCs) are critical workspaces for sterile handling, mixing, and transfer of sensitive biological materials. These cabinets are designed to maintain product protection, operator safety, and environmental containment.
However, sterility inside a BSC depends entirely on the precision and compliance of human behavior:
Hand and tool movement must follow strict unidirectional airflow patterns
Surfaces must be disinfected methodically
No cross-zoning or glove contamination is allowed
SOP violations can invalidate entire batches or experiments
Despite well-documented protocols, these processes remain manual, unaudited, and vulnerable to deviation — often only addressed after something goes wrong.
The Graypaw Solution: Cognitive SOP Monitoring with GrayVisions
In collaboration with Proconex, GRPAW is piloting a vision-based compliance monitoring system inside BSCs, using the GrayVisions platform.
This system uses discreetly installed fisheye cameras inside the BSC — requiring only a few minutes to mount, with no need for precise alignment — to enable continuous cognitive monitoring of operator behavior during critical procedures.
Pipeline capabilities:
Object and hand tracking within the sterile field
Detection of critical SOP deviations (e.g., bidirectional movement, cross-contamination risk)
Motion and dwell time analysis
Verification of surface disinfection patterns and durations
Historical event tagging and video-linked metadata for QA review
Supervisors are notified of violations in real time or post-procedure, with access to annotated video, incident summaries, and operator-specific metrics — all without needing to enter the cleanroom.
Pilot Scope & Deployment
The pilot, currently underway at the Jefferson Institute for Bioprocessing, includes:
- Multi-camera deployment across multiple BSCs
- Real-use procedural recordings with live annotation feedback
- Operator onboarding in simulated and semi-live GMP conditions
Initial use cases focus on training gap identification, real-time SOP violation alerting, and video-assisted deviation reviews to support quality teams and auditors.
Target Outcomes
Increased procedural compliance inside sterile zones
Reduced hidden deviations and contamination risks
Enhanced audit readiness with visual evidence
Lower supervisor workload through remote validation
Training reinforcement via real activity playback
“Every movement inside a BSC matters. GrayVisions turns compliance from invisible to actionable.”
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